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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 10 Documents
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Search results for , issue "Vol 21 No 2, 2010" : 10 Documents clear
Development of ciprofloxacin radiopharmaceutical formulation in single vial Nurlaila Z; Maula Eka S; Eva Maria W
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.9 KB) | DOI: 10.14499/indonesianjpharm0iss0pp139-149

Abstract

Bacterial infection diseases is the greatest death causes in Indonesia. Detection of the deep-seated infection location caused by the gram positive and gram  negative  bacteries  could  be  done  with  nuclear  technique  using 99mTc-ciprofloxacin  radiopharmaceutical.   In  order  to  fulfill  the  necessity  of  this radiopharmaceutical,  the  development  of  formulation in  single  vial  based  on Sn(II)  chloride  and  tartaric  acid  instead  of  Sn(II) tartrat  has  been  carried  out. The  aim  of  this  investigation  is  to  obtained  the  optimum  condition of 99mTc-ciprofloxacin  preparation  with  maximum  labelling efficiency. Several  parameters  influencing  the  labelling  process  of 99mTc-ciprofloxacin such  as  the  amount  of  tartaric  acid,  pH  of  the  reaction,  the  amount  of  Sn(II) ion  as  a  reducing  agent  and  the  incubation  time  has been  studied.   The labelling  efficiency  and  the  radiochemical  purity  of 99mTc-ciprofloxacin  were determined  by  double  chromatography  system  using  Whatman  I/methyl ethyl  keton  to  determine  the  free 99mTc-pertechnetate  and  ITLCSG/(ethanol:water:ammonia = 2:5:1) to separate  the free 99mTc-reduced. The  optimum  preparation  condition  was  obtained  at  pH  =  2.95-3.20,  2  mg  of ciprofloxacin,  0.06  µg  of  tartaric  acid,  50  µg  of  SnCl2—2H2O  and  15  minutes incubation  time  at  room  temperature,  gave  90-93  %  of  labelling  efficiency,  in wchich was stable for 20 minutes at room temperature. Beside that, studies on the  effect  of  Na99mTcO4  solution  volume  to  the 99mTc-ciprofloxacin   labelling efficiency  was  carried  out.   Labelling with up to 0.3 mL of Na99mTcO4 solution volume gave less than 90 % labelling efficiency.Key words: radiopharmaceutical, ciprofloxacin, 99mTc, single vial
Characterization antibacterial constituent from Ficus deltoideusJack leaves Suryati .; Hazli Nurdin; Dachriyanus .; Md Nordin Hj Lajis
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.054 KB) | DOI: 10.14499/indonesianjpharm0iss0pp134-138

Abstract

An antibacterial constituent, has been isolated from Ficus deltoideus Jack leaves. Based on spectroscopic data (IR, 1H-NMR, 13 C NMR 1D and 2D and MS), the structure of this compound was identified as Olean-12en-3β-ol, (β-amyrin), C30H50O. This compound showed antibacterial activities against E. coli, B. subtilis and S.  aureus.  The minimum inhibition concentration (MIC) agains  E.  coli,  B. subtilisand  S. aureusare 230, 380 and 460 (µg/mL) respectively.Key words: Antibacterial activity,Ficus deltoideusJack, β-amyrin
Radiation exposure of radiation workers from 1997 – 2006 based on the criteria and working period toto Trikasjono; Zainul kamal
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.961 KB) | DOI: 10.14499/indonesianjpharm0iss0pp106-114

Abstract

The external acceptance dose of radiation worker inYogyakarta have been studied.  This  research  was  done  in  this   three  specific  areas  A,B,C,  because  of worker  in  this  trihedral  have  hit  high  probability  radiation  exposure.  Radiation exposure worker were taken from each  worker  who  wears  Thermoluminescent Dosimeteron period 1997-2006. Exposure result of radiation is done every year in  Laboratory  Safety,  Health  and  Environment,  Centre  of  Research  and Development  Safety  Radiation,  National  Nuclear  Energy  Agency.  This  research aim  is  to  know  how  much  exposure  dose  of  radiation  accepted  by  worker radiation weather have been fulfilled or not the system limitation of dose which have  been  specified  by  International  Commission  on  Radiological  Protection (ICRP)  and  or  Nuclear  Energy  Regulation  Agency   and also  determine furthermore  step  to  guarantee  health  and  safety  worker  radiation  worker. Radiation  worker  that  chosen  as  sample  of  research  are  45  workers  that  are radiation worker. Data collection which is used in this research using personnel radiation monitors.  The  result  of  this  analysis  indicate  that  distribution acceptance of annual dose personal of group interval 0-2 mSv, and acceptance of highest dose 6.09 mSv in the year 1998 from section A. Whole acceptance of dose of external personal at worker from third monitored area, still below the dose  of  limitation  Nuclear  Energy  Regulation  Agency  which  is  recommended  is 50 mSv/year and ICRP 1990 is 20 mSv/year.Key words: personal radiation exposure, radiation worker, radiation
Evaluation of side effect of risperidon on schizophrenic patient in Amino Gondohutomo hospital Semarang M. Caecilia N Setiawati; Nanang Munif Yasin; Septiana Laksmi R
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.762 KB) | DOI: 10.14499/indonesianjpharm0iss0pp77-82

Abstract

Schizophrenia  is  a  psychiatrical  chronical  disease  of  human  being’s  mind which  can  influence  someone  so  that  it  bothered  the interpersonal  relation  and ability to have a social relationship. Antipsychotic drug can be used to overcome the  symptom of  schizophrenia, for  example risperidone.  This  study was  aims to evaluate the side effects of the use of risperidoneon the inpatient of Dr. Amino Gondohutomo  Mental  Hospital  Semarang  for  a  month  in the  period  of  February 2008.  This  evaluation  covers  the  side  effects  of  medicine  that  occur  due  to  the use  of  risperidone,  concomitant  administration  of  risperidone  and  other antipsychotic,  drug  interaction,and  also  executed  therapy  of  the  side  effects  of the  risperidone.  This  study  followed  the  descriptive  analysis,  while  the  data collecting  was  conducted  prospectively.  The  subjects  of  research  were represented  by  the  entire  patients  of  the  inpatient ward  of  Dr.  Amino Gondohutomo Mental Hospital Semarang during the period of February 2008 and fulfilled  the  inclusive  criteria.  The  inclusive  criteria  covered  the  patients  who were diagnosed as paranoid schizophrenia, hebephrenic schizophrenia, catatonic schizophrenia,  undetailed  schizophrenia  and  received  anti-psychotic  risperidone medication.  Based  on  these  criteria  31  samples  were found.  The  result  of  the study indicated that the most possibility of side effects of the use of risperidone was  agitation  (19.51  %),  with  the  most  anti-psychotic  combination  of risperidone  and  haloperidol  (45.83  %)  and  there  were  15  interactions  which could potentially cause a drug side effect.Key words: schizophrenia, drug side effects, anti-psychoticrisperidone
Synthesis of Tetrahydro Pentagavunon-0 Ritmaleni, Ritmaleni; Simbara, Ari
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.499 KB) | DOI: 10.14499/indonesianjpharm0iss0pp100-105

Abstract

Curcumin,  tetrahydrocurcumin,  and  monoketone  curcumin  analogue, pentagamavunone-0  (PGV-0),   have  been  investigated  as  antioxidant,  antiinflammatory  and  anticancer.  This  research  was  aimed  to  synthesise  the Tetrahydropentagamavunone-0  (THPGV-0)  compound  which  assumed  as  an active  metabolite  of  PGV-0.  The  hydrogenation  reaction  was  applied  to  the synthesis  of  THPGV-0  from  PGV-0  using  Pd/C  10  %  as  catalyst  at  room temperature.  The structure elucidation  was  analysed by  using  spectroscophy method. The synthetic result showed that THPGV-0 asa white crystalline powder in 25 % with melting point about 122-123 oC.Key words: pentagamavunone-0, Tetrahydropentagamavunone-0, hydrogenation
Effect of gambir extract Uncaria gambierRoxb. on fetal of pregnant mice induced by alcohol A, Almahdy
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.198 KB) | DOI: 10.14499/indonesianjpharm0iss0pp115-120

Abstract

Anomaly  in  the  fetus  of  mice  may  induced  by  the  present  of  oxidative stress on the dam during gestation. Alcohol is a potential substance that able to generate the oxidative stress. Antioxidant theoretically should reduce the above process.  Gambir  extract  is  a  notorious  non  toxic  herbal  which  rich  of antioxidants.  This  study  aims  to  see  whether  the  oxidative  stress  in pregnant mice  induced  by  alcohol  could  be  suppressed  with  gambir  extracts.  The results showed that administration of gambir extract to thepregnant dam of mice after been induced by alcohol during gestation, reduced the presence of a thrombus on the pup.Key words: Gambir extract, ethanol, teratogen, mice
Optimization of sorbitol, glycerol, and propyleneglycol mixture in sunscreen gel of ethanolic extract of Curcuma mangga Yuliani, Sri Hartati Hartati
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.168 KB) | DOI: 10.14499/indonesianjpharm0iss0pp83-89

Abstract

The research about optimization of sorbytol, glycerol, and propyleneglycol mixture  in  sunscreen  gel  of  ethanolic  extract  of  Curcuma  mangga has  been done.  The  aims  of  this  research  was  to  discover  the optimum  mixture  of sorbytol,  glycerol  and  propyleneglycol  that  gave  good  physycal  characteristic  of the  gel.  First, made the ethanolic extract of Curcuma mangga as active ingredient.  The SPF value of the ethanolic extract of Curcuma mangga was measured.  Simplex  lattice  design  was  employed  to  create  the  optimum composition  of  sorbitol,  glycerol  and  propyleneglycol  in  the  sunscreen  gel. Physical characteristic of the gel including spreadability, viscosity and the alteration of the gel viscosity was measured. The result showed that there were optimum composition between sorbytol, glycerol and propyleneglycol which gave good  physical  characteristics  based  on  the  shading  area  at  the  counterplot superimposed.Keywords: sorbitol, glycerol, propyleneglycol, Curcuma mangga, sunscreen gel
Prevalence and control of hypertension among diabetes patients in hospital universiti sains malaysia, malaysia Salwa Selim Ibrahim; Ayman Selim I. Bougalambou; Fita Rahmawati; Mohamed Azmi Hassali; Syed Azhar Syed Sulaiman
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.715 KB) | DOI: 10.14499/indonesianjpharm0iss0pp121-128

Abstract

Hypertension  in  patients  with  type  2  diabetes  mellitus  is  a  prevalent condition that leads to substantial morbidity and mortality. The aim of the study was  to  determine  the  prevalence  of  hypertension  in  type  2  diabetes  attending endocrinology  clinics  at  Hospital  Universiti  Sains  Malaysia  (HUSM),  to  describe antihypertensive  treatment  patterns,  and  to  evaluate  the  target  of  blood pressure  achieved  by  antihypertensive  agents.  The  study  was  a  prospective follow-up  descriptive  study.  Study  conducted  at  diabetic  clinic  outpatient  at HUSM,  Kelantan,  Malaysia  from  January  to  December  2007.  A  total  of  1077 diabetic patients involve in this study. The findings of our study showed that the majority patients type 2 diabetes mellitus 998 (92.7 %) had hypertension. For the  patients  who  were  on  antihypertensive  medications,  254  (23.6  %)  of  them were  on  monotherapy  and  311  (28.9  %),  179  (16.6  %), and  198  (18.4  %) respectively  received  two,  three  and  more  than  three  antihypertensive  agents. The majority of patients 872 (87.4 %) were on angiotensin converting enzyme inhibitors/angiotensin receptor blockers either alone or in combination with other antihypertensive  drugs.   A  number  of  601  (55.8  %)  patients  achieved  blood pressure  targets  ≤  130/80  mm  Hg.   Almost  all  patients  with  hypertension  anddiabetes will require a combination of antihypertensive medications. A number of patients was not achieved blood pressure goals ≤ 130/80 mm Hg. There is still need  to  educate  both  patients  and  health  care  providers  of  importance  of achieving target of blood pressure in order to reduce morbidity and mortality in diabetes mellitus patients.Key words: Hypertension, type 2 diabetes mellitus, hypertension treatment
Effects of pentagamavunon-0 on histaminemediated hyperresponsive airway in asthmatic models : in-vitro in-vivo Agung Endro Nugroho; Hemmy Prasetyo; Djoko Suhardjono; Mulyono Zhang Be; Shuang Liu; Supardjan A. Margono; Kazutaka Maeyama
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.397 KB) | DOI: 10.14499/indonesianjpharm0iss0pp90-99

Abstract

Asthma  is  a  chronic  inflammatory  airway  disease  involving  reversible airway  constriction  and  airway  hyperresponsiveness  (AHR)  to  allergens,  airway edema,  and  increased  mucus  secretion  tumor  cells.  To  date,  exploration  of antiasthmatic  drug  is  still  being  studied  both  from natural  products  or  sinthetic processes.  One of the sinthetic compound is pentagamavunon-0  (PGV-0)  which possesses anti-inflammatory and inhibitory effects on histamine release from rat mast cells. The aim of the study is to look at the effects of PGV-0 on histaminemediated hyperresponsive airway in asthmatic models (in vitro and in vivo studies).  In  vitro  study  was  conducted  using  isolated  organ  technique  with isotonic  transducer.  The  results  have  shown  that  PGV-0  could  not  inhibit  the contraction  of  isolated  guinea  pig  trachea  induced  by  histamine.  PGV-0 did not change  the  pD2 and  Emax  values  of  histamine  on  trachea  smooth  muscle.  The finding  indicates  that  PGV-0  does  not  have  affinity and  intrinsic  activity  on  H-1 histaminergic  receptor  in  trachea  smooth  muscle.  In vivo  study,  we  sensitized the  rats  with  ovalbumin  (OVA)  to  develop  the  airway hyperreactivity  to histamine.  Histamine  level  in  bronchoalveolar  lavage  fluid  (BALF)  and  airway tissue  were  determined  using  HPLC-fluorometry.  Multiple  exposures  of ovalbumin  significantly  histamine  level  in  BALF  by  74.51±5.33  pmol/mL  or 6-times  higher  than  this  of  control  saline  group.  Oral  administration  of  PGV-0 (40  mg/kg  BW)  significantly  decreased  the  histamine accumulation  in  BALF  to 30  %  of  the  value  of  control  group  in  asthmatic  rats.  Besides,  PGV-0 significantly  prevented  the  histamine  decrease  in  asthmatic  rats  to  37.8  % trachea, and 34.2 % in bronchus. However, PGV-0 did not succeed to prevent the histamine decrease in the lung of asthmatic rats.  The result of the study may provide useful information for further discovering pharmacological synthetic compound for treatment of allergic inflammatory asthma.Key words: asthma, curcumin, pentamavunon-0, histamine, airway hyperresponsiveness 
Anti-inflammatory activity of dominant compound of mahkota dewa fruit Phaleria macrocarpa Scheff. Boerl Mariani, Ria; Wirasutisna, Komar Ruslan; Nawawi, As’ari; Adnyana, I Ketut
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.241 KB) | DOI: 10.14499/indonesianjpharm0iss0pp129-133

Abstract

The anti-inflammatory effectof dominant compound of mahkota dewa fruit (Phaleria macrocarpaScheff. Boerl), a hydroxyl benzophenon glucoside,to Wistar  female  rats  (using  λ-karagenan  as  inflammatory  inducer)  has  been investigated.   The inflammation was measured by pletismometer.  The test has been used physiology NaCl solution as a control andNaproxen at a dose of 22.5 mg/kg body weight as a standard. Anti-inflammatorytest was showed that the decreased  inflammation  of  the  isolate  at  a  dose  of  22.5  mg/kg  body  has  twice lower than the standard.Key words:  Phaleria  macrocarpa,  anti-inflammatory  activity,  hydroxyl  benzophenon glucoside

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